How CBD interacts with our endocannabinoid system to treat anxiety

Table of Contents

Every day it is more and more common for a person of any age to comment that they have or have had anxiety. What is anxiety? Do we all have it? Can CBD help me control this symptom? 

Anxiety is defined as a fear and discomfort accompanied by physical symptoms (sweating palms, tachycardia, chest pain, etc.). This represents one of the most frequent mental health disorders in the population, often interfering with the work or daily life of the person who suffers from it.

A concept to differentiate is that of anxiety with fear. The latter is an adaptive response to a specific, known, external threat that is not caused by a conflict; On the other hand, anxiety occurs as a response to a non-specific, internal, vague threat or caused by some conflict.

But anxiety itself is not bad, it helps us to make an adaptive response to stressful situations, with the aim of preparing the body to be alert to a situation that represents a danger. Now when these adaptive responses of the organism are constant for a long time, they can become uncontrollable and chronic and end up affecting the person's quality of life. 

Traditional treatments vary depending on the severity at which symptoms interfere with patients' lives. There are conditions of mild anxiety where there is an excellent symptomatic response to a multidisciplinary approach with psychotherapy, meditation, physical activity, detoxification from social networks and screens, sleep hygiene recommendations, a Mediterranean diet low in processed products and high in fruit and vegetables, adequate hydration, smoking cessation, etc. If symptoms persist despite lifestyle changes and psychotherapy, the specialist may consider the use of psychoactive drugs such as benzodiazepines, pregabalin and selective serotonin reuptake inhibitors.

Endocannabinoid system, a fundamental advance in science

In 1992, Professor Raphael Mechoulam and his team at the University of Israel discovered the first endogenous cannabinoid produced by our own body, which has a chemical structure very similar to the products of the cannabis plant, called Anandamide. Later they discovered others such as 2-arachidonylglycerol. This research advance was fundamental to the understanding that the human body produces endogenous cannabinoids (endocannabinoids) that bind to specific receptors (cannabinoid receptors) and activate them to produce different effects (Imbalance Response). 

The cannabinoids produced by the body and cannabinoid receptors make up the endocannabinoid system, which is widely distributed in the organism of all mammals and is involved in multiple metabolic pathways, acting as a regulatory body on cellular physiology.

The objective of this system is to maintain the balance of the organism in its entirety, attending to regulate the situations in which the body does not function correctly, to return to achieve body homeostasis. 

When there is no regulation of our body, the endocannabinoid system increases the production of endocannabinoids. Many times this is not enough, it is there that phytocannabinoids such as CBD used exogenously play a fundamental role in combating a symptom.

How to use CBD for anxiety symptom?

A key point is to understand that the endocannabinoid system modulates brain function by balancing it. There is abundant scientific evidence that links the appearance of severe episodes of anxiety with the alteration of this system. The main phytocannabinoid for the proposed treatment is cannabidiol (CBD) which does not have any psychoactive effect and helps stimulate the regulation of body balance when it binds to specific receptors. 

It should be noted that cannabinoids potentiate the action of benzodiazepines and increase their effect. That is why in people with these treatments it is necessary to carry out a close control in the dosage of CBD. It is very important not to stop taking benzodiazepines suddenly, since the withdrawal syndrome caused by sudden suspension of these drugs can be very severe, so it is essential to have the supervision of a doctor specialized in medical cannabis for its correct approach.

To conclude, scientific evidence and extensive clinical experience recommend varieties rich in CBD. If possible they also contain limonene, myrcene or linalool.. If possible they also contain limonene, myrcene or linalool. CBD oil used sublingually is one of the main recommendations as a complementary base treatment, since the duration of the phytocannabinoids in this route lasts approximately eight hours. It is usually started with extracts in high dilutions (1/100), in three daily doses with one to two sublingual drops, gradually increasing until the effective dose is found. The Vaporized route gives us the advantage of rapid action and is useful as a rescue treatment in the event of crisis episodes, or as a treatment for various symptoms such as insomnia, for example. Two puffs of CBD at 180 degrees are usually indicated, then wait five minutes and evaluate the response. If the discomfort continues, another puff is recommended, increasing the amount depending on the needs of each organism. It is important to remember that tetrahydrocannabinol (THC) used in high doses can cause anxiety states.

Anxiety is a symptom that affects a large portion of the population today. The problem of high work stress, excessive use of social networks, sedentary lifestyles, smoking, poor nutrition means that to solve this problem, we need to acquire interdisciplinary resources in order to achieve changes in styles and lifestyles, as they are; doing mostly aerobic controlled physical activity, Mediterranean diets rich in fruits and vegetables and low in processed products, treatment with psychotherapists and/or psychiatrists along with a CBD approach can help a person suffering from anxiety find a solution that allowing him to fully develop without having this debilitating symptom. It is essential to consult a professional trained in the subject so that clinical and symptomatic improvement is effective and safe.

This article has been reviewed and approved by Dr. Jordi Domingo Rivas

Psychiatrist with more than 25 years of experience in his specialty, created in 1998 the medical society Instituto NEPP S.L.

Article written by Pedro Bosco Veiga

Doctor graduated from the National University of the South, Argentina. PM: 3637.

Other entries of interest:

Best sellers


No, CBD oil will not get you high. Full-spectrum CBD oil, created from the hemp plant, is naturally low in THC; therefore, it would take a lot of CBD for you to experience a “high” feeling. If you want to avoid any interaction with THC, buy a THC-free broad-spectrum CBD product.
CBD oil interacts with our body's endocannabinoid system, the system that exists throughout the body to help us maintain balance and homeostasis. A balanced system supports the relief of common problems: aches and pains, joint pain, skin and sleep problems, and much more.
The manufacture of our oils is to extract the cannabidiol (CBD) and the terpenes from the hemp plant with CO2. The combination of these compounds is what gives us the appreciated (entourage effect) where the cannabinoids unite and work together to achieve a more powerful effect. Made in Germany under the supervision of experts, passing through several quality controls and complying with EU regulations. The broad-spectrum WEEDNESS CBD oil is free of the psychoactive substance Tetrahydrocannabinol (THC), so it cannot cause euphoric or psychoactive effects. Even though our CBD oil is an ecological product, free of pesticides, free of (THC) and being a very beneficial product for both humans and our animal friends, we at WEEDNESS CBD do not recommend the consumption of Cannabidiol (CBD) in pregnant or lactating women before contacting your doctor. Since we well know that pregnancy and lactation are very delicate processes and based on scientific studies that still cannot say anything clearly about it.
CBD oil stay in our system between 2 days and 1 week. However, it is possible that for some, CBD can stay in their system much longer. Many factors influence how long CBD oil will stay in your system, including height, weight, exercise level, and water intake, to name a few.
CBD will affect everyone differently. People generally feel more relaxed and at ease after consuming CBD. However, some report feeling alert and focused. The best way to find out how CBD oil makes you feel is to try it for yourself.
The information offered, referenced or linked to this website is for informational purposes only and does not provide medical or legal advice.
None of our products contain THC, so using any WEEDNESS CBD product cannot result in a positive test for doping or prohibited substances. Each product has a QR code with its corresponding analytics. If you need more information about analytics, contact our team
Currently CBD is a substance under study which will be able to establish the correct daily amount. (25mg/day) is generally considered to be a “low dose” daily. The “average dose” is between (25-50 mg/day) Doses higher than (75-100 mg/day) are considered as “high doses”. Although the consumption of CBD oil is not allowed in Spain, there are other countries in the EU and the US where its sublingual consumption is popular and regularized. There, CBD users recommend starting with a "low dose" of 2-3 sublingual drops and gradually increasing the amount until you get your "perfect dose" and obtain the desired effect. Being a natural product, taking the same amount does not affect everyone in the same way. In Spain at the moment CBD oil can only be used for topical use. Applying it in areas with inflammation, pain (such as arthritis), skin with acne, seborrhea, atopic dermatitis and psoriasis.
CBD oil is used to help support healthy inflammatory function, promote a healthy sleep/wake cycle, help relieve persistent pain, and much more.
The CBD oil that shows up on a drug test depends on the amount of CBD you ingest and the type of CBD you consume. CBD oil created from a hemp plant contains trace amounts of THC (less than 0.2%) but will not produce a “high”. However, if you want to play it safe, always buy a broad-spectrum CBD oil, which does not contain THC.
No, Weedness CBD Broad Spectrum CBD Oils does not contain THC.
No, hemp oil is not the same as CBD oil. Hemp seed oil is produced from cold-pressed hemp seeds. CBD oil is extracted from the flowers of the hemp plant. Hemp seed oil does not contain CBD, while CBD oil contains high concentrations of the cannabinoid CBD.
Cannabidiol or CBD, as it is better known, is legal in Spain as long as it contains less than 0.2% THC. All of our products are THC-free, making them 100% legal.
CBD is a molecule that has led to a large number of scientific studies showing that controlled consumption of CBD provides numerous beneficial health effects. This cannabinoid found in the Cannabis Sativa L. plant has proven to be an effective substance in the treatment of diseases such as arthritis, asthma or epilepsy. These scientific advances culminated in the report published in December 2017 by the World Health Organization (WHO) stating that CBD is neither addictive (unlike THC, the psychoactive component of the cannabis plant) nor has any harmful effects on health, while confirming its enormous therapeutic potential.

Latest BLOG Posts

How CBD interacts with our endocannabinoid system to treat anxiety

CBD oil: effects on memory

Does CBD help with asthma?

Leave a Reply

Your email address will not be published. Required fields are marked *

The reCAPTCHA verification period has expired. Please reload the page.

Información básica sobre protección de datos Ver más

  • Responsable: Weedness CBD SL.
  • Finalidad:  Moderar los comentarios.
  • Legitimación:  Por consentimiento del interesado.
  • Destinatarios y encargados de tratamiento:  No se ceden o comunican datos a terceros para prestar este servicio. El Titular ha contratado los servicios de alojamiento web a Online que actúa como encargado de tratamiento.
  • Derechos: Acceder, rectificar y suprimir los datos.
  • Información Adicional: Puede consultar la información detallada en la Política de Privacidad.

Accede a tu cuenta


To subscribe